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Nucleotides

Nucleotides

Nucleotides

How nucleotides shape the culture 

The Culture of the Laminae

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Dorsal (Posterior) Horn:

contains neurons that receive somatosensory information from the body, which is then transmitted via the ascending pathways

It receives sensory information from the body via the dorsal roots of the spinal nerves

The dorsal root emerges from the spinal cord and travels to the dorsal root ganglion (DRG), a collection of nerve cell bodies

Dorsal Horn Neurons:

local interneurons:

These are a specific type of interneuron that connect and process information within a small, localized area of the central nervous system, such as the spinal cord

typically have short axons and only interact with neighboring neurons

and projection neurons:

specifically within the dorsal horn, are the output cells that relay processed sensory information, including pain and itch, from the spinal cord to the brain, with populations found in lamina I and deeper laminae

process this sensory information, including pain, temperature, touch, and proprioception (awareness of body position)

The dorsal root continued 

The processed sensory information is then relayed to the brain via, ascending pathways (e.g., the dorsal column-medial lemniscal pathway)

deal with the conscious appreciation of fine touch, two-point discrimination, conscious proprioception, and vibration sensations from the entire body except for the head

The dorsal horn contains various neurotransmitters that transmit peripheral information to spinal cord neurons,

excitatory: 

Excitatory neurotransmitters increase the likelihood of a neuron firing an action potential by depolarizing the postsynaptic membrane

meaning making the inside of the cell less negative (more positive) relative to the outside

When a neurotransmitter binds to receptors on the postsynaptic membrane, it can cause ion channels to open, allowing positively charged ions (like sodium, Na+) to flow into the cell

neurotransmitters including:

glutamate:

acts as the primary excitatory neurotransmitter, crucial for spinal excitatory synaptic transmission, pain perception, and sensory information processing

inhibitory:

prevent or decrease the likelihood of a nerve cell firing an action potential, thus playing a crucial role in regulating neuronal activity and preventing overexcitation

GABA:

GABA is an amino acid that functions as a neurotransmitter, a chemical messenger

glycine:

Glycine exerts its inhibitory effects by binding to specific glycine receptors (GlyRs), which are ionotropic receptors that open chloride channels

When glycine binds to GlyRs, chloride ions flow into the neuron, causing hyperpolarization and inhibiting neuronal firing

Neurotransmitters:

nitric oxide (NO):

a gas, acts as a unique neurotransmitter, diffusing across cell membranes and affecting nearby cells, rather than being stored and released like conventional neurotransmitters. It plays a role in synaptic plasticity, learning, and memory, and can also have neurotoxic and neuroprotective effects. 

prostaglandins:

while not neurotransmitters themselves, are potent lipids that act as modulators of neurotransmission, influencing the release and action of neurotransmitters like norepinephrine. They are considered local hormones or autacoids, playing a role in various physiological functions, including inflammation and pain

adenosine triphosphate (ATP):

acts as a neurotransmitter and a cotransmitter in both the central and peripheral nervous systems, mediating various functions through activation of P2X and P2Y receptors

endogenous opioids:

also known as neuropeptides, produced naturally in the body that act as neuromodulators, influencing pain, emotion, reward, and other functions by binding to opioid receptors in the brain and spinal cord

monoamines (serotonin and norepinephrine)

Serotonin (5-hydroxytryptamine): Regulates mood, sleep, appetite, and other functions

Norepinephrine (also called noradrenaline):Plays a role in alertness, arousal, and the "fight-or-flight" response

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Folklore

Folktales explaining the first region of Organelle 

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Ventral (Anterior) Horn:

largely contains motor neurons that exit the spinal cord 

contains the cell bodies of motor neurons, which send axons via the ventral roots to innervate skeletal muscles

ventral roots are bundles of axons that carry efferent (motor) signals from the spinal cord to the body's skeletal muscles, emerging from the spinal cord laterally towards the anterior surface

It's primarily a motor region, meaning it contains the neurons responsible for sending signals that cause muscles to contract

The ventral horn contains two types of lower motor neurons: 

alpha motor neurons

which supply the extrafusal muscle fibers with nerves 

outside the muscle spindle - a sensory receptor 

gamma motor neurons

which supply the intrafusal muscle fibers with nerves 

located within a muscle spindle - a sensory receptor 

Sensory receptors are specialized cells that detect stimuli from the internal or external environment and convert them into electrical signals for the nervous system to interpret

Part of the body’s Proprioception system 

the ability to sense the position and movement of our body parts, mediated by specialized receptors (proprioceptors) in muscles, tendons, and joints, allowing us to move and maintain balance without relying solely on vision

Specialized sensory receptors, like muscle spindles and Golgi tendon organs, are located in muscles, tendons, and joints

The brain processes this information, creating a "mind's eye" view of our body's position and movement

 The axons of these motor neurons exit the spinal cord via the ventral roots, which are part of the spinal nerves

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Folklore

Folktales explaining the second region of Organelle 

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Human Mitochondrial DNA

Human Mitochondrial DNA

Folklore

Folktales explaining the first circle 

Feline Mitochondrial DNA

Feline Mitochondrial DNA

Folklore

Folktales explaining the second circle 

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The World Of The Dead

What is experienced in the world of the dead is that everything to be built is in reverse compared to the world of the living 

Meiosis in reverse, Chromosomes in reverse, nucleotides in reverse, you get the picture 

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